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KMID : 0359320170570030181
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Korean Journal of Veterinary Research
2017 Volume.57 No. 3 p.181 ~ p.187
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Antihypertensive effect of ethanol extracts of Aralia elata in spontaneously hypertensive rats
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Jin Ju-Youn
Park Eun-Hye
Jeon Yoon-A
Lee Young-Jae
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Abstract
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Antihypertensive effects of ethanol extracts of Aralia elata (Miq.) Seem. (AE) were investigated in spontaneously hypertensive rats (SHR). SHR aged 14 weeks were treated for 8 weeks with AE (10 or 50 mg/kg/day) or amlodipine besylate (Am; 10 mg/kg/day) orally. Hypertension results in injury to several organs and can produce a significant increase in malondialdehyde (MDA) content as a result of lipid peroxidation and endothelial dysfunction. In this study, oral administration of AE and Am significantly reduced systolic blood pressure, organ weight index, and MDA content in tissues but increased significantly the plasma nitrite and nitrate concentrations. The endothelium-dependent relaxant activities of acetylcholine ((10^-10)?(10^?3) M) in norepinephrine (NE)-precontracted aorta were increased in AE- and Amtreated rats. Particularly strong endothelium-dependent relaxant activities were observed in AE-treated (50 mg/kg) rats. The endothelium-independent relaxant activities of sodium nitroprusside ((10^-10)?(10^?3) M) in NE-precontracted aorta were not changed. The results of this study suggest that AE has both antihypertensive and end-organ protective effects in SHR.
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KEYWORD
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Aralia elata, hypertension, lipid peroxidation, nitic oxide
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